Effect of short-term treatment with metformin on psychological distress and metabolic feature in patients with polycystic ovary syndrome
10.3760/cma.j.issn.1000-6699.2013.03.006
- VernacularTitle:二甲双胍短期治疗对多囊卵巢综合征患者心理异常和代谢特征的影响
- Author:
Tao TAO
;
Wei LIU
;
Jialiang MAO
;
Yun JIA
;
Ping ZHANG
- Publication Type:Journal Article
- Keywords:
Polycystic ovary syndrome;
Psychological distress;
Metformin;
Treatment
- From:
Chinese Journal of Endocrinology and Metabolism
2013;(3):211-215
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of short-term treatment with metfbrmin on psychological distress and metabolic feature in patients with polycystic ovary syndrome(PCOS).Methods Ninety women were diagnosed as cases of PCOS based on the 2003 Rotterdam criteria.These patients were divided into three groups:group A,consisted of 26 subjects treated with mefformin only; group B,36 cases treated with metformin plus Dane-35 ; and group C,28 cases treated with placebo and Dane-35.The treatment was carried out for 3 months.Clinical and metabolic parameters were observed.The psychological distress was evaluated by the hospital anxiety and depression scale(HAD scale).Results Compared with group C,patients in group A and B showed significantly lower body mass index(BMI),waist circumference (WC),waist-hip ratio (WHR),serum fasting insulin,homeostasis model assessment for insulin resistance (HOMA-IR),total cholesterol (TC),triglyceride (TG),low density lipoproteincholesterol(LDL-C) levels as well as anxiety and depression scores,but higher high density lipoprotein-cholesterol (HDL-C) levels (all P＜0.05).Compared with group A,patients in Group B had significantly higher WC,WHR,and LDL-C levels(all P＜O.05).No significant differences in BMI,TG,HDL-C,anxiety and depression scores were found between group A and B (all P＞0.05).In group A,a positive correlation was found between the changes of metabolic feature (BMI,WHR,and HOMA-IR) and the changes of anxiety and depression scores (all P ＜0.05).Conclusion Short-term treatment with metformin will benefit patients with polycystic ovary syndrome,regarding psychological distress and metabolic features.
