Effectivity of continuous positive airway pressure in treatment of chronic obstructive pulmonary disease complicated with left heart failure
10.3760/cma.j.issn.0254-9026.2013.01.014
- VernacularTitle:无创呼吸机治疗老年人检慢性阻塞性肺病合并左心衰竭的疗效分析
- Author:
Yingyu LIU
;
Hongyang WANG
;
Lei ZHANG
- Publication Type:Journal Article
- Keywords:
Ventilator,negative-pressure;
Pulmonary disease,obstructive;
Heart failure
- From:
Chinese Journal of Geriatrics
2013;(1):55-57
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical effectivity of continuous positive airway pressure in treatment of chronic obstructive pulmonary disease complicated with left heart failure.Methods Totally 103 patients (aged 63-78 years) with chronic obstructive pulmonary disease complicated with left heart failure were randomly divided into two groups:treatment group (received noninvasive ventilation combined with routine medication) and control group (received conventional drug therapy).The patients of two groups were observed in the treatment of 1 hour to one week that blood pressure (SBP),heart rate (HR),arterial blood gas analysis,respiratory rate (RR),brain natriuretic peptide (BNP) and other indicators to improve the situation.Results After treatment,the PaO2 level of patients in treatment group was significantly increased from (56.1 ± 7.8) mm Hg to (91.1 ±11.3)mm Hg,(t=449.94,P＜0.05),PaCO2 decreased from (60.1± 10.9) mm Hg to (42.3± 9.3)mm Hg,(t=4.66,P＜0.05),pH value was improved from (7.26±0.12) to (7.36±0.17) (t=5.88,P＜0.05) and BNP was decreased from (350±181) ng/L to (961±376) ng/L (t=8.07,P＜0.05).In control group,the PaO2 was significantly increased from (55.0±8.1) mm Hg to (89.1±12.0) mm Hg (t=43.17,P＜0.05) after treatment,PaCO2 by decreased from (48.9±10.8) mm Hg,(58.9±10.8) mm Hg to (t=5.13,P＜0.05),pH value by up to (7.27 ±0.08),BNP by decreased from (439 ± 246) ng/L to (947 ±407) ng/L t=9.81,P＜0.05.Compared with the control group,the difference of PaO2 and BNP had no significantly significant.PaCO2 in treatment group was increased more sharply than it in the control group,and pH decreased more (P＜0.05 or P＜0.01).Conclusions The use of continuous positive airway pressure to treatment chronic obstructive pulmonary disease complicated with left heart failure can alleviate fatigue and prevent the respiratory failure.It is remarkable treatment effect and worthy of clinical application.
