The role of Hedgehog signaling pathway effective proteins in hepatocellular carcinoma
10.3760/cma.j.issn.1007-8118.2013.03.009
- VernacularTitle:肝细胞肝癌中Hedgehog信号通路效应蛋白的功能分析
- Author:
Linghua YU
;
Xinguang YIN
;
Yawei YU
;
Wanxin WU
;
Yanping ZHANG
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Gli1 protein;
Gli3 protein
- From:
Chinese Journal of Hepatobiliary Surgery
2013;(3):198-200
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study analyzes the expression and clinical significance of Gli1 and Gli3 proteins in hepatocellular carcinoma.Methods 36 patients with hepatocellular carcinoma were studied.The expressions of Gli1 and Gli3 in the carcinoma and adjacent non-tumor tissues were detected with immunohistochemical assay,and their correlations with clinicopathological factors were statistically analyzed.Results Expression rates of Gli1 in hepatocellular carcinoma and adjacent nontumor tissues were 75 ％ and 36.1％,respectively.Expression rates of Gli3 in hepatocellular carcinoma and adjacent non-tumor tissues were 58.3％ and 30.6％,respectively.Expression rates of Gli1 and Gli3 in hepatocellular carcinoma were significantly higher than in adjacent non-tumor tissues (P＜0.05),and a positive correlation was found between the expression of Gli1 and Gli3 (r=0.423,P＜0.05).There was no association between the expression of Gli3 and clinicopathological factors such as age,tumor size,tumor differentiation and lymphatic metastasis.The expression of Gll1 was not related witha patient's age and tumor size,hut there were significant associations with tumor differentiation and lymphatic metastasis.Conclusions Therefore,the expression rate of Gli1 was positively correlated with tumor malignancy,which makes the detection of Gli1 and Gli3 valuable for the diagnosis and prognosis of hepatocellular carcinoma.
