99mTc-GSA SPECT imaging in liver diseases
10.3760/cma.j.issn.1007-8118.2013.01.025
- VernacularTitle:99mTc-GSA SPECT显像在肝脏疾病中的应用
- Author:
Jing CHEN
;
Jiansheng LI
;
Geliang XU
;
Weidong JIA
;
Jinliang MA
- Publication Type:Journal Article
- Keywords:
Asialogycoprotein receptor;
Techneti-um-99m-DTPA-galactosyl human serum albumin;
Single photon emission computed tomography;
Hepatic functional reserve
- From:
Chinese Journal of Hepatobiliary Surgery
2013;(1):75-78
- CountryChina
- Language:Chinese
-
Abstract:
Asialogycoprotein receptor (ASGPR) is a specific receptor of mammalian hepatocytes,exclusively up-take the glycoprotein in the blood.The number of ASGPR correlates significantly with liver function,and the reduction of the number of ASGPR suggest liver dysfunction.Decreased ASGPR in patients with liver cirrhosis or portal hypertension or hepatocellar carcinoma,lead to varying degrees of liver dysfunction,which made it more susceptible to post operative complications.liver ASGPR scintigraphy with Technetium-99 m DTPA-galactosyl human serum albumin (99m Tc-GSA),combinating with single photon emission computed tomography (SPECT) technology can assess the functional reserve of remnant liver and predict incidence of postoperative complications,then assist to evaluate the use fulness for clinically surgical decisions.Current situation and progress of 99mTc-GSA SPECT imaging in hepatic surgery were reviewed in the paper.
