Decoy receptor3 in rheumatoid arthritis patient and its clinical relevance
10.3760/cma.j.issn.1007-7480.2013.01.005
- VernacularTitle:类风湿关节炎患者血清中诱骗受体3的检测及临床意义
- Author:
Rulin JIA
;
Jing ZHAO
;
Xiaolin SUN
;
Lingyun SUN
;
Zhanguo LI
;
Xia LI
- Publication Type:Journal Article
- Keywords:
Arthritis,rheumatoid;
Receptors,tumor necrosis factor,member 6b;
Rheumatoid factor;
Anti-cyclic citrullinated peptide antibodies
- From:
Chinese Journal of Rheumatology
2013;(1):20-22
- CountryChina
- Language:Chinese
-
Abstract:
Objective To test serum decoy receptor 3 (DcR3) concentration in patients with rheumatoid arthritis (RA),and analyze its clinical significance.Methods The serum from 180 RA patients,29 osteoarthritis (OA) patients,60 systemic lupus erythematosus (SLE) patients,30 Sj(o)gren's syndrome (SS) patients and 100 healthy donators were selected.The serum DcR3 concentrations of the two groups were detected by enzyme-linked immunosorbent assay (ELISA).The correlation between serum DcR3 levels and clinical features of patients with RA were investigated.T test,x2 test and Spearman's correlation analysis were used for statistical analysis with software SPSS 16.0.Results Serum DcR3 levels in RA patients [(202±261)ng/ml] were significantly higher than those of the healthy controls [(32±31) ng/ml,t=5.33,P＜0.01],OA patients [(90±33)ng/ml,t=1.998,P＜0.01],SLE patients [(41±56)ng/ml,t=3.19,P＜0.01],and SS patients [(25±31) ng/ml,t=2.50,P＜0.01].The DcR3 cut value was 45.86 ng/ml for the diagnoses of RA,the sensitivity and specificity was 0.991 and 0.765 respectively.The levels of serum DcR3 in RA patients were related with rheumatoid factor (RF) IgM,RF-IgG,anti-cyclic citrullinated peptide antibodies (anti-CCP) and C3.Conclusion Serum DcR3 level is significantly elevated in RA and it is significantly associated with immunological index of RA including RF-IgM,RF-IgG,C3 and anti-CCP antibody,which may be a factor for unfavorable prognosis of RA patients.
