Experiment of the ultrasound radiation force enhancement in adhesion of targeted microbubbles in vivo

Baoping Wang; Fenglin WU; Lijing JI; Tingting XU

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Experiment of the ultrasound radiation force enhancement in adhesion of targeted microbubbles in vivo

VernacularTitle:超声辐射力促靶向微泡黏附的在体实验研究
Author: Baoping WANG ; Fenglin WU ; Lijing JI ; Tingting XU
Publication Type:Journal Article
Keywords: Ultrasonography; Microbubbles; Intercellular adhesion molecule-1
From: Chinese Journal of Ultrasonography 2013;(3):255-258
CountryChina
Language:Chinese
Abstract: Objective To investigate the effects of ultrasound radiation force(USRF) on adhering of targeted microbubbles in vivo.Methods A rat model of cremaster muscle Inflammation was developed,and microbubble(MB) or targeted microbubble of intercellular adhesion molecule-1 (MBICAM) was injected through the caudal vein.Immediately after intravenous MB or MBICAM injection,the cremaster was insonated for 5 minutes and the control group was in sham ultrasound exposure.All mice were divided into four groups randomly:① MB + false USRF; ② MB + USRF; ③ MBICAM + false USRF; ④ MBICAM + USRF.Fluorescence microscope was performed in twenty mice to evaluate microbubbles adhesion and video recordings were made with a high-resolution camera.Results The adhesion number of MBICAM was significantly greater in USRF group than that of MBICAM in false USRF group [(43.4 ± 2.1)/view vs (14.8± 1.8)/view,P =0.000].The adhesion number of MB in USRF group was greater than in false USRF group [(6.2 ± 1.3)/view vs (4.6 ± 0.9)/view].But there is no statistical significance (P =0.129).The adhesion number of MBICAM in both USRF group and false USRF group was significantly greater than the adhesion number of MB.Conclusions The ultrasound radiation force can significantly improve the adhesion of targeted microbubbles in vivo.