Mechanism of nonsteroidal anti-inflammatory drugs induced gastric mucosa injury
10.3760/cma.j.issn.1008-6315.2013.04.010
- VernacularTitle:非甾体抗炎药相关胃黏膜损伤机制的研究
- Author:
Zhiguang ZHANG
;
Wei LU
;
Man LI
;
Shujun WEN
;
Yinglan JI
;
Xiuli XIA
- Publication Type:Journal Article
- Keywords:
Non-steroidal anti-inflammatory drug;
Vascular endothelial growth factor;
Malondialdehyde;
Hypoxia inducible factor-1α
- From:
Clinical Medicine of China
2013;(4):358-360
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expression of Vascular Endothelial Growth Factor (VEGF),Malondialdehyde (MDA),Hypoxia Inducible Factor-1 α (HIF-1 α) in the Non-Steroidal Anti-Inflammatory Drug (NSAID)-associated gastric mucosa injury tissue,and to understand the mechanism of NSAID induced gastric mucosa injury.Methods We collected 114 biopsy specimen of gastric mucosa under endoscope from patients admitted to our hospital,including 70 cases with NSAID-associated chronic erosive gastritis or gastric ulcer (NSAID group) and 44 cases with chronic superficial gastritis who never take NSAID as controls (the control group).Immunohistochemistry technique was used to detect the positive expressions of VEGF,MDA,HIF-1α in patients.Results The positive rate of VEGF expression in the NSADI group was significantly lower than that in the normal control group (25.7％ (18/70) vs.54.5％ (24/44),x2 =9.70,P ＜ 0.05).The positive rates of MDA and HIF-1α in the NSADI group were significantly higher than these in the normal control group (MDA:62.9％ (44/70) vs.27.3％ (12/44),x2 =13.70,P ＜0.05; HIF-1α:45.7％ (32/70) vs.13.6％ (6/44),x2 =12.50,P ＜ 0.05).Conclusion NSAID drugs may induce gastric mucosa injury by decreasing the expression of VEGF and increase the levels of MDA and HIF1-α in gastric mucosa tissue.
