A case of Waldenström's macroglobulinemia treated using clarithromycin and prednisolone.
10.12793/tcp.2017.25.3.134
- Author:
Masashi OHE
1
;
Satoshi HASHINO
;
Haruki SHIDA
;
Tetsuya HORITA
;
Mitsuru SUGIURA
Author Information
1. Department of Internal Medicine, JCHO Hokkaido Hospital, Sapporo, Japan. masshi@isis.ocn.ne.jp
- Publication Type:Case Report
- Keywords:
Macroglobulinemia;
Lymphoma;
Clarithromycin;
Prednisolone
- MeSH:
Aged, 80 and over;
Blood Platelets;
Bone Marrow;
Clarithromycin*;
Female;
Hematuria;
Hemophilia A;
Hemorrhage;
Humans;
Immunoglobulin M;
Immunoglobulins;
Lymphoma;
Omentum;
Prednisolone*;
Tooth Extraction;
Waldenstrom Macroglobulinemia*
- From:Translational and Clinical Pharmacology
2017;25(3):134-137
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report a case of Waldenström's macroglobulinemia (WM) treated using clarithromycin (CAM) and prednisolone (PSL). An 84-year-old woman was admitted to our hospital for bleeding after a tooth extraction and hematuria. Computed tomography showed multiple ill-defined nodules in the omentum (omental cake). Although the cause of the omental cake remained unclear, the patient was diagnosed with WM, based on the detection of M-protein of immunoglobulin (Ig) M in serum and lymphoplasmacytes in bone marrow. The bleeding tendency in the patient may have been due to acquired hemophilia and/or hyper IgM-induced platelet dysfunction. The patient was treated using CAM (800 mg/day) and PSL (10 mg/day). As a result, IgM levels gradually decreased. Because the omental cake contracted along with improvement in IgM, it was thought to be lymphoplasmacytic lymphoma-like lymphoma. This case shows that treatment using CAM and PSL may be effective in some cases of WM.
