Effects of Jianpizhidong decoction on dopamine D2 receptor mRNA in striatum of tourette' s syndrome model mice
10.3760/cma.j.issn.1674-6554.2013.04.003
- VernacularTitle:健脾止动汤对多发性抽动综合征模型鼠纹状体多巴胺D2受体mRNA的影响
- Author:
Xiaofang LIU
;
Sumei WANG
;
Li WEI
;
Daohan WANG
;
Li LI
- Publication Type:Journal Article
- Keywords:
Tourette;
Striatum;
Dopamine D2 receptor;
Jianpizhidong decoction;
Mice
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2013;(4):296-298
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of traditional Chinese medicine of Jianpizhidong decoction on dopamine D2 receptor(DAD2R) mRNA in tourette syndrome (TS) model mice brain striatum,and provide the proof of neural biochemical for Jianpizhidong decoction in curing children TS.Methods 32 male ICR mice were divided randomly into control group,model group,Jianpizhidong decoction group and Tiapride group.Except control group,all mice in model group,Jianpizhidong decoction group and Tiapride group were made to TS models by intraperitoneal injection of 3,3'-iminodipropionitrile.The control gronp and model group were given normal saline,Jianpizhidong decoction group and Tiapride group were given corresponding drugs by intragastric administration respectively.Results The striatum DATmRNA expression of model group,Tiapride group,and traditional Chinese medicine group decreased(respectively(0.139 ± 0.013),(0.15 ± 0.021),(0.141 ± 0.019)) than that of control group (0.180 ± 0.028),and with 14.1％,3.0％ and 3.9％ down respectively.In model group DATmRNA expression was lower than control group (P ＜ 0.01).In model group DATmRNA expression was lower than Tiapride group (P＜ 0.01).In model group DATmRNA expression was lower than traditional Chinese medicine group (P＜0.01).In Tiapride group DATmRNA expression was lower than traditional Chinese medicine group (P ＜ 0.01).Conclusion The function of improving symptoms of TS by Jianpizhidongtang may be relate to inhibite DAD2R hypersensitization to enhance the activity of substantia nigra-striatum.
