Obsevsation on the effect of docetaxel combined with 5-fluorouracil and cisplatin in the treatment of patients with advanced gastric cancer
10.3760/cma.j.issn.1008-6706.2013.07.005
- VernacularTitle:多西紫杉醇联合氟尿嘧啶治疗晚期胃癌的疗效观察
- Author:
Ling ZHAO
;
Ming HUANG
;
Yinshan YANG
;
Hua TAN
;
Xin ZHAO
- Publication Type:Journal Article
- Keywords:
Docetaxel;
Fluorouracil;
Stomach neoplasms
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(7):971-973
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and adverse effects of docetaxel combined with 5-fluorouracil in treating patients with advanced gastrice cancer.Methods 130 patients with advanced gastric cancer were randomly divided into observation group and control group,observation group treated with docetaxel combined with 5-fluorouracil,the control group treated with 5-fluorouracil and cisplatin,the clinical efficacy after the treatment was observed.Results The clinical efficiency rate of the observation group was significantly higher than that of the control group,the rate of leukopenia,thrombocytopenia and gastrointestinal reactions of the observation group was significantly lower than the control group,the quality of life scores of the two groups after treatment were all improved,but that of the observation group was significantly higher than the control group,the difference was statistically significant(P ＜ 0.05).Conclusion Docetaxel combined with 5-fluorouracil was effective in treating advanced gastric cancer.It worth further clinical research and application.
