Expression of c-myc, c-myb and c-erbB-2 protein in breast cancer
10.3760/cma.j.issn.1008-6706.2013.05.001
- VernacularTitle:癌基因蛋白c-myc、 c-myb、 c-erbB-2在乳腺癌组织中的表达
- Author:
Dechun LIU
;
Yunxia ZHAO
- Publication Type:Journal Article
- Keywords:
Breast cancer;
C-myb;
C-myc;
C-erbB-2;
Pathology;
Immunohistochemistry
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(5):641-643
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the roles of aberrant expression of c-myc,c-myb,and c-erbB-2 in the development of breast cancer and its clinical significance.Methods Immunohistochimical technique (S-P method)was used to detect the expression of c-myb,c-myc and c-erbB-2 protein in 150 cases of breast cancer and 30 cases of benign proliferative lesions.heir relation to clinical pathological parameters were analyzed.Results The protein expression levels of c-myc,c-myb,and c-erbB-2 in breast cancer were higher than those in benign proliferative lesions and the difference was significant(all P ＜0.05).Expression of c-myc protein had obvious relationship to histological grade,lymph nodes metastasis and pathological types(all P ＜ 0.05).Expression of c-myb protein related significantly to histological grade (P ＜ 0.05).c-erbB-2 was associated with the tumor size,grading,PR expression (all P ＜ 0.05).The association among the three kinds of genetic proteins was observed.Conclusion Expressions of oncogenes c-myc,c-myb,and c-erbB-2 proteins are higher in breast cancer and lower in benign proliferative lesions.The difference is significant.They are related to the grading and some other prognostic factors such as tumor size,pathologic types,PR expression and lymph node metastasis.The results suggest that these oncogenes are activated in the development of breast cancer and provoke cancerous cells multiplication.Expressions of oncogenes c-myc,c-myb and c-erbB-2 mightbe considered to be the prognostic indicators of breast cancer.
