The changes of the coagulation indicators in the process of lymphoma patients with autologous blood stem cell transplantation

VernacularTitle:淋巴瘤患者自体血造血干细胞移植过程中凝血指标的变化
Author: Jinhong JIANG ; Bingmu FANG ; Zhigang QU ; Yehui XU ; Yemin ZHOU ; Shuping LIU
Publication Type:Journal Article
Keywords: Lymphoma; Hematopoietic stem cell transplantation; Transplantation,autologous; Fibrinogen; Prothrombin time
From: Chinese Journal of Primary Medicine and Pharmacy 2013;20(7):969-970
CountryChina
Language:Chinese
Abstract: Objective To explore the inflnence of autologous peripheral blood hematopoietic stem cell transplantation (auto-HSCT) for lymphoma process on the quality of patients blood coagulation.Methods Plasma samples were collected before the conditioning and on day 0,7,14,28,35 follow auto-HSCT from 20 patients.The following parameters were measured:prothrombin time (PT),activated partial thromboplastin time (APTT),fibrinogen (FIB) and D-dimer(D-Di).Results Compared with the values before conditioning,a significant rise in the FIB values was detected on day 7 and day 14 after auto-HSCT,no essentially change in the FIB values was detected on day 21 and day 28 and day 35 after auto-HSCT.Other coagulation parameters investigated(PT.APTT.D-Di) remained essentially unchanged.All of the patients not concurrent thrombotic disease.Conclusion Lymphoma patients with autologous peripheral blood hematopoietic stem cell transplantation appear abnormality in coagulant function.Clinical doctors should concern.