The change of the serum level of cystatin C, urinary NAG enzyme in the children affected by HSP and its clirical significale
10.3760/cma.j.issn.1008-6706.2013.07.003
- VernacularTitle:过敏性紫癜肾损伤儿童血清胱抑素C、尿N-乙酰-β-D-氨基葡萄糖苷酶水平变化及其意义
- Author:
Weihua LIU
;
Bin YANG
;
Beining ZHANG
;
Qiufang KANG
- Publication Type:Journal Article
- Keywords:
Purpura,schoenlein-henoch;
Renal insufficiency;
Cystatin C;
Acetylglucosaminidase
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(7):966-968
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the change of the serum levels of cystatin C,urinary NAG enzyme in the children affected by HSP and its cliracal significance.Methods 60 children with HSP were divided into three groups based on urine routine and abnormal degrees of biochemícal examination results,which were kidney injury group A (KI-Group A),kidney injury group B (KI-Group B),and non-kidney injury group (non-KI-Group).Selected 28 healthy children with the same phase and the same age as the control group.A sandwich enzyme-linked immunosorbent assay(ELISA) was employed to determine the values of cystatin C,urinary NAG enzyme.Results Urinary NAG enzyme in KI-Group A (127.11 ± 15.63) ng/L and KI-Group B (132.75 ± 19.83) ng/L were significantly higher than the control group (111.36 ± 20.10) ng/L (F =7.324,P ＜ 0.05),and there was no difference between non-KI-Group (108.14 ± 13.83) ng/L and the control group.Cystatin C in KI-Group A (1.18 ±0.13) mg/L,KI-Group B (1.19 ±0.17)mg/L and non-KI-Group (1.16 ±0.11)mg/L were all significantly higher than the control group (0.79 ±0.14)mg/L (P ＜ 0.05).Conclusion Cystatin C and urinary NAG enzyme in children with HSP were significantly abnormal,and may be used as early indexes reflecting the glomerular injury.The relationship of the two above indicators had positive correlation,and the combined employment of them had the dadvantages of early detection,high sensitivity and accurate diagnosis.
