The influence of different dosages of atorvastatin in acute coronary syndrome female patients on vascular endothelial growth factor and brain natriuretic peptide

VernacularTitle:不同剂量阿托伐他汀对女性急性冠脉综合征患者血浆血管内皮生长因子和脑钠肽的影响
Author: Qian DU ; Ling QIN
Publication Type:Journal Article
Keywords: Coronary disease; Vascular endothelial growth factor; Brain natriuretic peptide; Female
From: Chinese Journal of Primary Medicine and Pharmacy 2013;20(2):244-246
CountryChina
Language:Chinese
Abstract: Objective To study the influence of different dosages of atorvastatin in acute coronary syndrome female patients on vascular endothelial growth factor(VEGF) and brain natriuretic peptide(BNP).Methods 60 female cases of ACS patients were divided into A and B group.30 patients in the A group were given atorvastatin 20mg per night,while the other 30 patients in the B group were taken 40mg per night.The patients were followed four weeks by evaluating serum VEGF and BNP concentration.Results After treatment for four weeks,the patients in the two groups showed significant reduction in VEGF and BNP,however,the therapeutic group showed significant difference between the two groups.Additionally,the B group further showed significant reduction in VEGF and BNP.Conclusion Using high-dose atorvastatin lowers VEGF and BNP significantly,which could reduce female cardiovascμlar events.