Effects of thymosin alpha 1 combined with neoadjuvant chemotherapy in breast cancer

VernacularTitle:胸腺肽α1对乳腺癌新辅助化疗后免疫功能的影响
Author: Shuanggen LEI ; Xiaofen YU ; Chunwei XIE ; Shixin YANG ; Ruijun ZHAO ; Qiumo LEI
Publication Type:Journal Article
Keywords: Breast neoplasms; Antineoplastic combined chemotherapy protocols; Thymosin alpha 1; T-lymphocyte subsets
From: Chinese Journal of Primary Medicine and Pharmacy 2013;20(6):851-853
CountryChina
Language:Chinese
Abstract: Objective To study the impact of the thymosin alpha 1 on the toxicity and celluar immune function during neoadjuvant chemotherapy of breast cancer.Methods 83 patients of Ⅱ b-Ⅲ a stage breast cancer were randomly divided into two groups:study group(40 patients,neoadjuvant chemotherapy of CEF combined with thymosin α 11.6mg HQD) and control group(43 cases,neoadjuvant chemotherapy of CEF alone).Results Rates of gastrointestinal reaction and bone marrow depression in study group were significantly lower than those in control group.The levels of CD3,CD4,CD4/CD8 and NK in study group were significantly higher than those in control group after chemotherapy.Conclusion The combination of thymosin alpha 1 and neoadjuvant chemotherapy for breast cancer can reduce the toxicity,improve the tolerance,enhance cellular immune function and improve the quality of breast cancer patient's life.