The effectiveness of valsartan on the insulin resistance and hs-CRP of patients with essential hypertension

VernacularTitle:缬沙坦对原发性高血压患者胰岛素抵抗及血清超敏C反应蛋白水平的影响
Author: Yurong XU ; Shuzhen WANG ; Lili ZHAO ; Xinhong XUE
Publication Type:Journal Article
Keywords: Hypertension; Insulin resistance; C-reactive protein; valsartan
From: Chinese Journal of Primary Medicine and Pharmacy 2013;20(6):823-825
CountryChina
Language:Chinese
Abstract: Objective To study the effectiveness of valsartan on the insulin resistance and high-sensitivity C-reactive protein(hs-CRP) of patients with essential hypertension.Methods One hundred and thirty patients with essential hypertension were randomly divided into two groups,the control group (n =65 cases) and the treatment group (n =65 cases).The patients in the control group were treated through amlodipine,while the patients in the treatment group were treated valsartan.They were all treated for six months.The insulin resistance(IR) and hs-CRP were compared.Results The systolic blood pressure and diastolic blood pressure were decreased after treatment in both groups (t =6.3706,6.4418,7.0519,7.2577,all P ＜ 0.01).There wasn't a significant difference between two groups (P ＞0.05).The IR and hs-CRP were decreased in both groups (t =6.3478,1.9977,4.0581,12.0722,all P ＜ 0.01).There was a significant difference between two groups (t =7.6049,4.6893,all P ＜ 0.05).Conclusion Valsartan can improve the insulin resistance and hs-CRP,which weren't dependent on lowing blood pressure.