The relation between vascular endothelial growth factor receptor 3 and bladder cancer lymphatic metastasis

VernacularTitle:血管内皮生长因子受体3与膀胱癌淋巴转移的关系
Author: Zhentao YANG ; Huien LIU ; Wanfeng ZHANG ; Hongjie WANG ; Xiaohui DING ; Ming LI ; Baifeng WANG
Publication Type:Journal Article
Keywords: Bladder cancer; Lymph node,metastasis; Vascular endothelial growth factor-C; Vascular endothelial growth factor receptor-3
From: Chinese Journal of Primary Medicine and Pharmacy 2013;20(5):678-680
CountryChina
Language:Chinese
Abstract: Objective To explore vascular endothelial growth factor-C (VEGF-C),vascular endothelial growth factor receptor 3 (VEGFR-3) in the bladder cancer tissue of the expression and the relationship with the tumor lymph node metastases of bladder cancer tissue,Methods The VEGF-C,VEGFR-3 expression was detected by Elivision TM plus two footwork.Results In 18 cases of bladder cancer organization,VEGF-C expression positive rate was 72％,VEGFR-3 express positive rate was 67％.VEGF-C in the bladder cancer of the transfer of the expression level compared to the lymph nodes of the transfer of the lymph node has not occurred to high.Conclusion In the bladder cancer organization and the surroundinglymph nodes,VEGF-C,VEGFR-3 expression level and lymph node metastasis is closely related.VEGF-C,VEGFR-3 expression intensity can be used as a lymph node metastasis in bladder cancer index.