Influence of CRRT on the functions of monocyte in patients with severe acute renal failure

VernacularTitle:连续性肾脏替代治疗对重症急性肾功能衰竭单核细胞功能的影响
Author: Yuanbiao LUO ; Xinhua PANG ; Huayan SU
Publication Type:Journal Article
Keywords: Continuous renal replacement therapy; Acute renal failure; Monocyte; Inflammation response
From: Chinese Journal of Primary Medicine and Pharmacy 2013;20(1):56-58
CountryChina
Language:Chinese
Abstract: Objective To investigate the effect of continuous renal replacement therapy (CRRT) on the function of monocyte in patients with severe acute renal failure (ARF).Methods The function of monocyte in 42 patients with ARF accepting CRRT was dynamically observed and compared with that of healthy people.Results Cytokine secreting function of monocyte in patients with ARF was stronger than that in healthy people[TNF-α:(1 212.61 ±107.43) vs (857.34 ±83.45) ng/L,IL-6:(2 518.22 ±228.22) vs (1 948.13 ±218.23) ng/L,IL-8:(416.18 ±54.46) vs (229.31 ± 39.83) ng/L] (t =6.47,7.09,6.45,all P ＜ 0.05) 48 h after CRRT,cytokine secreting function declined to normal.Conclusion CRRT corrects the disorder of cytokine secreting function of monocyte in patients with ARF,decreases the inflammation response.