Study on the influence of parenterai nutrition on nutritional status and immune function in breast cancer patients undergoing postoperative chemotherapy
10.3760/cma.j.issn.1008-6706.2013.04.007
- VernacularTitle:肠外营养支持对乳腺癌术后化疗患者营养及免疫功能的影响
- Author:
Le YANG
;
Yining XU
;
Jianming ZHU
- Publication Type:Journal Article
- Keywords:
Breast tumor;
Chemotherapy;
Parenterai nutrition;
Nutritional status;
Immune function
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(4):496-498
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of parenterai nutrition(PN) on nutritional status and immune function in breast cancer patients undergoing postoperative chemotherapy.Methods 94 patients with breast cancer postoperative patients were randomly divided into the treatment group(47 cases) and the control group(47 cases).All the patients were given chemotherapy with VBP.The treatment group was given glutamine fortified PN,and the control group was given normal nutrition support,respectively.The nutritional status and immune function before and after chemotherapy,and main toxicities were observed.Results Compared with those before chemotherapy,there were no significant decrease on the level of ALB,PA and HB in treatment group(all P ＞ 0.05),while those indicators in control group was significantly decreased (all P ＜ 0.05).After chemotherapy,CD4,CD8,CD4/CD8 and IgA,IgG,IgM levels of the two groups were lower than those before chemotherapy (all P ＜ 0.05),and the levels of immune indicators of the treatment group were significantly higher than those of the control group(all P ＜ 0.05).The main toxicities in two groups were nausea and vomiting,diarrhea and mild bone marrow suppression,and the body weight in control group decreased (0.91 ± 0.53)kg,while it increased (0.45 ± 0.21)kg in treatment group (t =5.53,P ＜0.05).Conclusion PN treatment for breast cancer patients during chemotherapy can improve nutrition status and immune function,enhance the tolerance of chemotherapy,so as to improve curative effect and prognosis.
