Influence of finasteride on the expression of hypoxia-inducible factor 1 α and vascular endothelial growth factor in the tissue of prostate cancer

VernacularTitle:非那雄胺对前列腺癌组织低氧诱导因子1α及血管内皮生长因子表达的影响
Author: Hongwei WANG ; Zhaohui JIANG ; Jie CHEN
Publication Type:Journal Article
Keywords: Finasteride; Prostate cancer; Hypoxia-inducible factor 1; Vascular endothelial growth factor
From: Chinese Journal of Primary Medicine and Pharmacy 2013;20(4):491-493
CountryChina
Language:Chinese
Abstract: Objective To study the influence of finasteride on the expression of hypoxia-inducible factor 1 α(HIF-1 α) and vascular endothelial growth factor (VEGF) with prostate cancer (Pca).Methods The patients diagnosed of Pca were selected,and which treated with finasteride for up to six months were finasteride group and untreated with finasteride were control group.The expression of HIF-1 α,VEGF and microvessel density(MVD) was examined.Results The positive expression of HIF-1α,VEGF and MVD in the finasteride group were 55.0％,57.5％,(56.9 ± 13.8),respectively,and were lower than those of the control group [87.5 ％,97.5 ％,(64.2 ± 13.3)] (x2 =10.313,18.122,all P ＜ 0.01 ; t =2.391,P ＜ 0.05).In the pathological grade,advanced grade of the finasteride group was in 15 cases(37.5％),and 10 cases(25.0％) was in the control group,and the difference was statistically significant between the two groups(x2 =1.455,P ＞ 0.05).Conclusion Long-term treatment with finasteride can reduce expression of HIF-1α and VEGF with Pca,thus inhibit angiogenesis and tumor growth and metastasis.