Curative effect analysis of mifepristone in the treatment of endometriosis and the influence on sex hormone levels isoforms expression
10.3760/cma.j.issn.1008-6706.2013.03.026
- VernacularTitle:米非司酮治疗子宫内膜异位症的疗效分析及其对性激素水平的影响
- Author:
Xuefang ZHU
;
Yuehua LUO
- Publication Type:Journal Article
- Keywords:
Mifepristone;
Endometriosis;
Estrogens;
Progestins;
Pituitary hormones,anterior
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(3):380-381
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore of curative effect analysis of mifepristone in treatment of endometriosis and the influence of sex hormone levels isoforms expression.Methods 70 cases of patients with endometriosis were randomly divided into the observation group and the control group with 35 cases in each group.The control group was treated by laparoscopic operation,postoperative unused drug therapy.The observation group was treated with laparoscopic operation,postoperative given mifepristone treatment.Results The complete remission rate of the observation group was 85.71％.It was higher than 62.86％ in the control group(x2 =4.786,P ＜ 0.05).The cumulative recurrence rate was 5.71％ in the observation group and the control group was 20％.It was lower than the control group (x2 =5.062,P ＜ 0.05).The level of estradiol (E2) and progesterone (P) after treatment in the observation group were lower than before treatment (t =5.171,3.632,all P ＜ 0.01).The level of luteinizing hormone (LH) and follicle stimulating hormone (FSH) after treatment were higher than before treatment (t =6.478,4.662,P ＜ 0.01).Conclusion Mifepristone is effective and safe to endometriosis.It can obviously improve sex hormone levels for the endometriosis patients.
