Comparison of the effect between postoperative chemotherapy in combination with radiotherapy and simple radiotherapy in malignant glioma

VernacularTitle:恶性脑胶质瘤术后放化疗联合与单纯放疗的疗效比较
Author: Bin DENG
Publication Type:Journal Article
Keywords: Brain neuplasms; Radiotherapy; Antineoplastic agents
From: Chinese Journal of Primary Medicine and Pharmacy 2013;20(3):360-362
CountryChina
Language:Chinese
Abstract: Objective To compare the efficacy of postoperative chemotherapy in combination with radiotherapy and simple radiotherapy in malignant glioma.Methods 82 patients with malignant glioma resection patients were randomly divided into observation group and control group,there were 41 patients in each group.The control were treated with simple three-dimensional conformal radiotherapy.The observation group were given temozolomide chemotherapy on the basis of three-dimensional conformal radiotherapy.The effects and adverse reactions were observed.Results Total effective rate of observation group was 63.4％ (26/41),significantly higher than that in the control group 34.1％ (14/41) (x2 =8.2439,P ＜ 0.01);gastrointestinal adverse reaction rates of the observation group was 100.0％,significantly higher than 58.5％ of the control (P ＜ 0.01),the difference of bone marrow suppression in two groups had no statistically significant (P ＞ 0.05).Conclusion Although with a higher incidence of gastrointestinal reactions,postoperative chemotherapy with radiotherapy have reliable effect,it is worth using in the condition of appropriate and timely symptomatic and supportive treatment.