Efficacy observation on mifepristone in the treatment of perimenopausal dysfunctional uterine bleeding
10.3760/cma.j.issn.1008-6706.2013.03.009
- VernacularTitle:米非司酮用于围绝经期功能失调性子宫出血的临床疗效观察
- Author:
Na WANG
;
Wei ZHAO
;
Lei SHI
- Publication Type:Journal Article
- Keywords:
Mifepristone;
Uterine hemorrhage;
Perimenopause
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(3):341-343
- CountryChina
- Language:Chinese
-
Abstract:
Objective To find out the clinical effects of mifepristone in the treatment of perimenopausal dysfunctional uterine bleeding.Methods 87 patients with perimenopausal dysfunctional uterine bleeding were received mifepristone treatment.The thickness of the endometrium and sex hormones indicators,including progesterone(P),estrogen (E2),the corpus luteum generated hormone (LH),follicle hormone (FSH),prolactin (PRL) and testosterone (T),were checked before and after treatment.Results The treatment efficiency was 90.8％.Endometrial thickness before treatment (10.9 ± 1.9) mm,endometrial thickness after treatment (5.4 ± 1.1) mm,with significant differences between them(t =0.684,P ＜ 0.01).After treatment,patients with hemoglobin (102.5 ± 7.1) g/L,significantly increased compared with before treatment (t =0.539,P ＜ 0.01).After treatment,the P,E2,LH,FSH levels were significantly lower than those of before treatment (t =0.690,0.552,0.513,0.376,all P ＜ 0.05) ; PRL,T levels after treatment compared with before treatment,there were no significant differences (all P ＞ 0.05).Conclusion The mifepristone treatment for perimenopausal uterine bleeding has high effective rate,less adverse reactions,and high clinical value.
