The establishing of renal transplantation model in non-human primate

VernacularTitle:非人灵长目动物-食蟹猴肾移植模型的建立
Author: Chuan ZHANG ; Qingguo ZHU ; Chengluo JIN ; Yakun ZHAO ; Yu QIU ; Kunlun LI ; Gangjun YUAN
Publication Type:Journal Article
Keywords: Primate; macaca; Kidney transplantation; Models,animal
From: Chinese Journal of Primary Medicine and Pharmacy 2013;20(3):326-328
CountryChina
Language:Chinese
Abstract: Objective To explore renal transplantation model in non-human primate cynomolgus monkeys.Methods 50 non-human primates' kidneys were transplanted into the lower part of the abdomen with end-to-side anastomosis of renal artery to aorta and renal vein to inferior vena eava,and with end-to-end anastomosis of ureter to bladder.Results In the 50 cases,1 case death as accident of anesthesia;7 cases with postoperative complications,and all with creatinine sudden rise,after ultrasonic examinations showed that 2 cases with renal vein thrombosis,and 5 cases appeared urinary leakage.All animal models were without surgical infections,and with normal serum creatinine,urine output.Conclusion Non-human primate animal kidney transplantation model establishment method is reliable,but should pay attention to the the surgical technique training,complications prevention.The model is valuable for application in the research of immune tolerance,heterogeneous transplant.