Clinical analysis of multiply antimicrobial-resistant bacteria and monitoring of antimicrobial resistance
10.3760/cma.j.issn.1008-6706.2013.01.011
- VernacularTitle:多重耐药菌感染的临床分析和耐药性监测
- Author:
Yan XIONG
;
Hong ZHANG
;
Yantian CHEN
;
Yongzhang RONG
- Publication Type:Journal Article
- Keywords:
MDRB;
Drug resistance;
Meta-analysis
- From:
Chinese Journal of Primary Medicine and Pharmacy
2013;20(1):26-28
- CountryChina
- Language:Chinese
-
Abstract:
Objective To provide an effective basis for clinical control methods of multi-drug-resistant bacterial (MDRB) infections by analyzing the distribution and antimicrobial resistance of MDRB.Methods The French Merieux ATB Expression Automated Analysis System was used for bacterial identification,whereas a drug susceptibility testing was performed by K-B methods.Drug-resistance rate was calculated,and the predisposing factors were analyzed.Results Altogether 811(8.1%) strains were isolated from 9 954 specimens,and the majority of multiply antimircobial-resistant bacteria were Escherichia coli,Coagulase-negative staphylococci,Klebsiella Pneumoniae Staphylococcus aureus,Acinetobacter Baumannii,Pseudommonas aeruginosa,whereas the last two appeared pan resistant strains.Specimen source was mainly from respiratory specimens,accounted for 47.8%,and was mainly distributed in the ICU unit,atout41.8% ;MDRB enterobacter was highly sensitive to Carbapenems with resistance rates less than 1.5% and to Amikacin and other inhibitor drugs that rate was less than 30.0%.The resistance rates of MDRB nonfermentative bacteria was > 77.0% to Carbapenem antibacterial drugs whereas to non-resistance was found to polymyxin and only 20.0% resistance rate to Cefoperazone/sulbactam.MDRB staphylococcus was 100.0% sensitive to Vancomyci,Teicoplanin and Linezolid and less sensitive (< 30.0%) to chloramphenicol and rifampicin.MDRB showed high resistance rate to other antibacterial drugs.The predisposing factors included age,other disease,hospitalization over two weeks,the usage of multiply antimicrobial especially cephalosporins overtoppinh 7 days,and invasive operations.Conclusion The major MDRBs are resistant to common-used antimicrobial drugs.It is nesessary to pay attention to the differences.