Effects of cyclooxygenase-2 expression on risk stratification and prognosis of patients with gastrointestinal stromal tumor: a Meta analysis
10.3760/cma.j.issn.1673-9752.2013.04.012
- VernacularTitle:环氧合酶-2表达与胃肠道间质瘤危险度分级的关系及对患者预后影响的Meta分析
- Author:
Fei LI
;
Feng CAO
;
Jia LI
;
Yu FANG
- Publication Type:Journal Article
- Keywords:
Gastrointestinal stromal tumor;
Cyclooxygenase-2;
Meta analysis
- From:
Chinese Journal of Digestive Surgery
2013;(4):285-289
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the effects of cyclooxygenase-2 (COX-2) on risk stratification and prognosis of patients with gastrointestinal stromal tumor (GIST).Methods Literatures in the Cochrane libraries of clinical comparative trials,PubMed,EMBASE,Cancer Lit and Chinese BioMedical Literature from 1966 to 2012 were retrieved using the Cochrane systematic evaluation method.The original data were extracted and crosschecked by 2 reviewers.The indicator for assessment including positive rates of COX-2 in GIST patients with different tumor diameters (＜5 cm versus ≥5 cm),mitosis of cancer cells (＜5/50 HPF versus ≥5/50 HPF) and National Institute of Health (NIH) risk stratifications (very low + low versus intermediate + high).The relationship between COX-2 expression and recurrence and metastasis of GIST was evaluated.All the data were analyzed using the RevMan 5.1 software with Meta analysis.The heterogeneity between studies was analyzed using the I2.The binary data were presented by odds ration (OR) and 95％ confidence interval (95 ％ CI).Results Seven articles with a total of 415 patients were included in the analysis.The COX-2 expression did not correlate with the tumor diameters,NIH risk stratifications and tumor metastasis and recurrence (OR =0.60,0.72,2.46,P ＞ 0.05),but with the mitosis of cancer cells (OR =0.46,P ＜ 0.05).Conclusion COX-2 expression is partly correlated with risk stratification of GIST,but has no effect on the prognosis.
