Clinical research of infants less than three months with kawasaki disease
10.3760/cma.j.issn.1673-4912.2013.01.016
- VernacularTitle:3月龄以下婴儿川崎病的临床研究
- Author:
Rong MI
;
Li LI
;
Xiaoying WANG
;
Limin KANG
- Publication Type:Journal Article
- Keywords:
Kawasaki disease;
Clinical manifestations;
Follow-up;
Coronary artery lesion;
Infant
- From:
Chinese Pediatric Emergency Medicine
2013;20(1):58-61
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical manifestations and prognosis of infants less than three months with kawasaki disease (KD).Methods Clinical manifestations,diagnosis,treatment and follow-up of the infants less than 3 months diagnosed with KD and hospitalized from Jan 2009 to Jan 2012 in Capital Institute of Pediatrics were collected and reviewed.Results Fourteen infants less than 3 months were diagnosed as KD during recent 3 years.Among them 8 cases were diagnosed as typical KD,6 cases as incomplete KD.The infants with KD had clinical features as fever longer than 5 d (14/14),cervical lymphadenopathy (11/14),rash (11/14),extremity changes (9/14),mucositis (10/14),conjunctivitis (5/14).Infants with incomplete KD had fever longer than 5 d (6/6) and extremity changes (4/6),cervical lymphadenopathy (3/6),rash (3/6).But fewer infants (2/6) had extremity changes later than 2 weeks.It was difficult to diagnose atypical KD earlier.More than half (8/14) of all the infants with KD had complications,6/14 had damaged liver function.Nearly all the cases (12/14) received intravenous immunoglobulin 1 g/.(kg·d) within 10 d of presentation.The coronary artery lesion was found in 2 infants during hospitalization.2 cases were found to have CAL during the follow-up after discharge from the hospital.The coronary artery lesion of the 4 infants recovered during follow-up.Conclusion Infants less than 3 months have higher rate of incomplete KD.All infants with KD should be followed-up and monitored for the coronary artery lesion.
