The Roles of Intercellular Adhesion Molecule I in T Cell Adhesion Tosynovial Cell in Patients with Rheumatoid Arthritis.
- Author:
Jae Bum JUN
1
;
Dong Yook KIM
;
Tae Hwan KIM
;
Seong Yoon KIM
;
Pyoung Nam KIM
;
Sung See JUNG
;
In Hong LEE
;
Sang Cheol BAE
;
Dae Hyun YOO
;
Soon Kil KIM
;
Seung Young KIM
Author Information
1. Rheumatism Center, Department of Internal Medicine*, College of Medicine, Hanyang University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Rheumatoid arthritis;
Intercellular adhesion molecule 1;
T cell-synoviocyte interaction
- MeSH:
Arthritis;
Arthritis, Rheumatoid*;
Cell Adhesion*;
Cell Communication;
Humans;
Intercellular Adhesion Molecule-1;
Interleukin-1;
Synovial Membrane;
T-Lymphocytes
- From:The Journal of the Korean Rheumatism Association
1995;2(2):119-125
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: It has previously been shown that cellular interaction between infiltrating mononuclear cells and synoviocyte are important in the initiation and perpetuation of autoimmune processes in the synovial tissue of patients with rheuamtoid arthritis. Thus, we have investigated the molecular basis of T cell-synovial cell interaction in the cultured synoviocytes from patients with rheumatoid arthritis. METHODS: Using an immunohistochemical staining technique and inhibition study with monoclonal antibody, we studied the expression and the function of intercellular adhesion molecule 1 (ICAM-1) in T cell-synovial cell interaction in the cultured synoviocytes. RESULTS: Expression of ICAM-1 was diffusely observed in most components of rheumatoid synovium and readily up-regulated by IL-1. T cell-synovial cell interaction was inhibited by monoclehal antibody aganinst ICAM-1. CONCLUSION: These results showed that ICAM-1 was involed in the cellular interaction between T lymphocytes and synovial cells in patients with rheumatoid arthritis.
