Observation on the influence of Shenqi-Fuzheng injection on T-lymphocyte subsets, NK cell and the leukocyte of the patients with advanced gastric cancer
10.3760/cma.j.issn.1673-4246.2013.01.007
- VernacularTitle:参芪扶正注射液对晚期胃癌化疗患者T细胞亚群、NK细胞、白细胞水平的影响
- Author:
Lili YIN
;
Chaoyong JIANG
- Publication Type:Journal Article
- Keywords:
Shenqi-Fuzheng injection;
Gastric cancer;
Immune function;
Leukocyte
- From:
International Journal of Traditional Chinese Medicine
2013;(1):22-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the term efficacy and the influence on the immune function and hemotology toxicity of Shenqi-Fuzheng injection to advanced gastric cancer patients combined with SP chemotherapy.Methods 53 patients with advanced gastric cancer were randomly divided into an observation group (26 cases) and a control group (27 cases).All patients were treated in the oncology department of the Chinese People's Liberation Army 264th Hospital during 2010.1 ～2012.6.The observation group accepted SP chemotherapy plus Shenqi-Fuzheng injection and the control group was treated with SP chemotherapy.After 2 cycles of chemotherapy the term efficacy was evaluated,cellular immune function index and hemotology adverse reaction were observed.Results The objective response rate (RR) between the treatment group and the control group had no difference (x2=0.024,P＞0.05).After 2 cycles of treatment,CD3+ (64.09±7.59)％,CD4+ (44.17±6.09)％,CD8+ (27.60±7.64)％,CD4+/CD8+ (1.63±0.66) and NK(28.07±7.28)％ in the observation group were higher than the control group [accordingly (54.64 ± 6.39) ％,(35.01 ± 6.05) ％,(24.29 ±7.41) ％,(1.30 ± 0.72),(25.06 ± 7.24) ％,(P＜ 0.05)].The incidence of leukocyte decline in the observation group was 19.23％,and 44.44％ in the control group.There was significant difference (P＜0.05).Conclusion Shenqi-Fuzheng injection plus SP chemotherapy can improve the cellular immune function and the tolerance to chemotherapy and reduce hemotology adverse of patients with advanced gastric cancer.
