Analysis of serum AGEs and sRAGE levels in newly diagnosed patients with type 2 diabetes
10.3760/cma.j.issn.1673-4246.2013.01.002
- VernacularTitle:初诊2型糖尿病患者血清晚期糖基化终末产物、可溶性糖基化终末产物受体水平分析
- Author:
Xiao CHEN
;
Xiaochun ZHOU
;
Weiming WU
;
Yixuan JIN
;
Lingling QIAN
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Advanced glycation end products;
Soluble receptor for advanced glycation end products
- From:
International Journal of Traditional Chinese Medicine
2013;(1):5-7
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the serum levels of advanced glycation end products (AGEs),soluble receptor for advanced glycation end products (sRAGE) in newly diagnosed patients with type 2 diabetes.Methods 60 patients of newly diagnosed type 2 diabetes were chosen from 2010 September to 2011 December in Department of Endocrinology Changshou Chinese medicine hospital in Jiangsu Province,and 30 healthy people were screened as control group.Various clinical and biochemical parameters were detected,using enzyme-linked immunosorbent assay for the detection of serum AGEs and sRAGE levels.Results The levels of serum AGEs in newly diagnosed type 2 diabetic patients and control group were (1379.2 ± 431.8) and (1154.5 ±326.4) pg/ml,and there were significant differences between two groups (P＜0.05).The levels of serum sRAGE in newly diagnosed type 2 diabetic patients and control group were (14.6± 9.3)and (19.5 ± 8.9)ng/ml,and there were also significant differences between two groups (P＜0.05).The level of serum AGEs in newly diagnosed type 2 diabetic patients was positive correlation with glycosylated hemoglobin (HbA1c),and the level of serum sRAGE was associated with low density lipoprotein cholesterol (LDL-C) negative correlation.Conclusion The level of serum AGEs increase in newly diagnosed type 2 diabetic patients,and the level of serum sRAGE decrease in newly diagnosed type 2 diabetic patients.
