Hedgehog signaling pathway and breast cancer stem cells
10.3760/cma.j.issn.1673-422X.2013.03.013
- VernacularTitle:Hedgehog信号通路与乳腺癌干细胞
- Author:
Ying SUN
;
Junmin WEI
;
Xiuwen WANG
- Publication Type:Journal Article
- Keywords:
Signal transduction;
Breast neoplasms;
Neoplastic stem cells;
Hedgehog
- From:
Journal of International Oncology
2013;(3):203-208
- CountryChina
- Language:Chinese
-
Abstract:
Hedgehog (HH) signaling pathway is a classic signaling pathway which controls embryonic development.Recent studies show that HH signaling pathway plays an important role in the tumorigenesis and development of cancer.Breast cancer stem cells (BCSCs) is closely associated with malignant tumor metastasis,relapse and treatment resistance.HH pathway plays crucial roles in maintaining the characters of BCSCs,and will probably become a novel therapeutic target of breast cancers.
