The Effect of Bucillamine of Trace Element Levels of Hair in Patients with Rheumatoid Arthritis.
- Author:
Jae Bum JUN
1
;
Dong Yook KIM
;
Tae Hwan KIM
;
Seung Young KIM
;
Pyoung Nam KIM
;
Sung Soo JUNG
;
In Hong LEE
;
Sang Cheol BAE
;
Dae Hyun YOO
;
Soon Kil KIM
;
Seong Yoon KIM
;
Beom Suk CHOI
Author Information
1. Rheumatism Center, Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Rheumatoid arthritis;
Trace element;
Hair;
Bucillamine
- MeSH:
Arthritis, Rheumatoid*;
Copper;
Hair*;
Humans;
Penicillamine;
Plasma;
Spectrum Analysis;
Zinc
- From:The Journal of the Korean Rheumatism Association
1995;2(2):126-132
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: We investigated the changes of trace element levels in hair of patients with rheumatoid arthritis after bucillamine treatment. METHODS: We performed inductively coupled plasma atomic emission spectrometry in determination of trace element levels in hair of patients with rheumatoid arthritis. RESULTS: The results were as follows: 1) There was a significant increase of copper concentration, but no change in zinc level after bucillamine treatment. 2) There were no significant changes in copper and zinc concentrations between the proximal and distal portions of hair after long-term bucillamine treatment. CONCLUSIONS: Our results showed the significant increase of copper level and no significant change of zinc level in hair after bucillamine treatment, but, although statistically not significant, copper and zinc levels were decreased on experiment with divided hair. So, our findings do not permit any conclusion on the influence of bucillamine on trace element levels in hair. Further studies in large samples and comparison with the effect of D-penicillamine will be necessary to clarify the association of trace element levels in hair of rheumatoid arthritis patients and bucillamine treatment.
