Bmi-1 gene and radiation resistance
10.3760/cma.j.issn.1673-422X.2013.03.007
- VernacularTitle:Bmi-1基因与放射抵抗的相关研究
- Author:
Beibei XIONG
;
Hua FAN
;
Tao LI
- Publication Type:Journal Article
- Keywords:
Neoplastic stem cells;
Radiotherapy;
Bmi-1 gene
- From:
Journal of International Oncology
2013;(3):184-187
- CountryChina
- Language:Chinese
-
Abstract:
As a transcriptional repressor,Bmi-1 is a member of polyeomb group gene family.It may play an important role in self-renewal ability and proliferation of stem cell.At present,studies show that Bmi-1 is highly expressed in a variety of solid tumors,which can be regarded as one of the markers of cancer stem cells and has a close relation to the cancer development and progression and radiation resistance.It will provide an important target gene for the treatment of malignant tumors.
