Clinical Trial of Dysprosium-165 HMA in the Treatment of Rheumatoid Knee Synovitis.
- Author:
Sang Cheol BAE
1
;
Dong Yook KIM
;
Tae Hwan KIM
;
Jae Bum JUN
;
Sung Soo JUNG
;
In Hong LEE
;
Dae Hyun YOO
;
Seong Yoon KIM
;
Sug Jun KIM
;
Jong Seok LEE
;
Dae Geun JEON
;
Soo Yong LEE
;
Sang Moo LIM
;
Kyung Bae PARK
;
Jae Rok KIM
Author Information
1. Rheumatism Center, Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea.
- Publication Type:Clinical Trial ; Original Article
- Keywords:
Dysprosium;
Radiation synovectomy;
Rheumatoid arthritis
- MeSH:
Arthritis, Rheumatoid;
Burns;
Dysprosium;
Follow-Up Studies;
Groin;
Humans;
Injections, Intra-Articular;
Joints;
Knee Joint;
Knee*;
Liver;
Radioactivity;
Range of Motion, Articular;
Synovitis*;
Visual Analog Scale;
Walking
- From:The Journal of the Korean Rheumatism Association
1995;2(2):133-140
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: To evaluate the efficacy and safety of radiation synovectomy with Dy-165 HMA in chronic rheumatoid synovitis of the knee METHODS: Two hundred thirty six knees of 212 patients with rheumatoid arthritis and persistent synovitis of the knee were treated with the intraarticular injection of 250~300 mCi of Dy-165 HMA which was prepared by KAERI. Efficacy was assessed by the following parameters: visual analog scale of the knee pain while walking and resting, circumference of the knee, range of motion of the knee. The final global assessment was classified as good, fair or poor. Estra-articular leakage of Dy-165 HMA was determined by blood pool and urine radioactivity and scintigraphic evaluation of liver, groin, and knee joints. RESULTS: l) The optimum radiation dose was 260mCi. 2) The mean follow up periods were 50.4(24-112) weeks. 3) Forty four percent of the knees showed good results, 32% fair results, and 24% shwoed good results. 4) In knees with stage I radiographic changes, 81% showed improvement, of which 54% showed good results. In knees with stage II changes, 78% showed improvement including 39% of the patients with good results. There was a direct correlation between the radiographic stage and response to treatment. 5) The mean period of improvement for the 180 knees that reponded to treatment was 41.4(24-106) weeks. Ten of the 180 knees with improvement relapsed after the mean period of 64(28-80) weeks. 6) Leakage of radioactivity from the injected joint was minimal. 7) Adverse reactions were rare(radiation burn : 4, transient postinjection "flare" : 14). CONCLUSIONS: The optimum radiation dose in Korean was somewhat less than of other foreign reports. Dy-165 HMA radiation synovectomy is a safe and useful therapy for chronic synovitis of the knee joint.
