Correlation between platelet membrane glycoprotein Ⅱb HPA-3 polymorphism and ischemic stroke in Chinese Han population
10.3760/cma.j.issn.1673-4165.2013.01.006
- VernacularTitle:血小板膜糖蛋白Ⅱb HPA-3基因多态性与中国汉族人缺血性卒中的相关性
- Author:
Dongliang WANG
;
Yan SUN
;
Xin LI
;
Ruifa HAN
;
Lin WANG
;
Jizuo WANG
- Publication Type:Journal Article
- Keywords:
Platelet Glycoprotein GPⅡ b-Ⅲ a Complex;
Polymorphism,Genetic;
Stroke;
Brain Ischemia;
Risk Factors
- From:
International Journal of Cerebrovascular Diseases
2013;(1):36-40
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution of glycoprotein (GP) Ⅱ b HPA-3 polymorphism in Chinese Han population in Tianjin and its correlation with ischemic stroke.Methods The patients in this study were divided into either a ischemic stroke group (n =150) or a control group (n =135).Genotyping was conducted by using polymerase chain reaction-restriction fragment length polymorphism and was verified by sampling sequencing Each genotype and allele frequency distribution and its correlation with ischemic stroke were compared.Results The ab genotype,bb genotype and b allele frequency in the patient group were significantly higher than those in the control group (P =0.000),while aa genotype and a allele frequency were significantly lower than those in the control group (P =0.000).There were no significant differences in the frequencies of GPⅡ b genotype and b allele between the different gender and the age groups in the patient group.Although there were no significant differences in genotype frequencies between all etiologic subtypes,b allele frequency in the large artery atherosclerotic stroke subgroup was significantly higher than that in the small vascular occlusive stroke subgroup and that in the cardioembolism subgroup (61.8％ vs.46.7％ vs.47.5％ ;x2 =6.573,P =0.037).Multivariate logistic regression analysis showed that hypertension (odds ratio [OR] 7.475,95％ confidence interval [CI]3.700-15.003; P =0.000) and b allele (OR 3.678,95％ CI 1.245-10.863; P =0.018) were the independent risk factors for ischemic stroke.Conclusions GP Ⅱ b HPA-3 polymorphism may be associated with the risk of ischemic stroke onset.Carrying b allele may be an independent risk factor for ischemic stroke,especially large artery atherosclerotic stroke.
