Correlation of 24 h microalbuminuria and cerebral microbleeds in patients with small artery occlusion: a retrospective case series study
10.3760/cma.j.issn.1673-4165.2013.01.003
- VernacularTitle:小动脉闭塞性卒中患者24 h微量白蛋白尿与脑微出血的相关性:回顾性病例系列研究
- Author:
Haixian ZHU
;
Min ZHANG
;
Fuqiang ZHONG
;
Lei ZHAO
;
Xianlin GAO
- Publication Type:Journal Article
- Keywords:
Cerebral Hemorrhage;
Stroke;
Brain Ischemia;
Albuminuria;
Risk Factors;
Biological Markers
- From:
International Journal of Cerebrovascular Diseases
2013;(1):19-22
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk factors for cerebral microbleeds (CMBs) and its correlation with the 24 h microalbuminuria (mALB) in patients with small artery occlusion (SAO).Methods The patients with SAO were enrolled.CMBs were detected with susceptibility-weighted imaging.The demographic and clinical characteristics and 24 h mALB of the patients were compared.Multivariate logistic regression analysis was used to identify the independent risk factors for CMB in patients with SAO.Spearman correlation analysis was used to investigate the correlation between the 24 h mALB and the degree of CMBs.Results A total of 90 patients with SAO were enrolled and 35 patients (38.89％) had CMBs.CMBs mainly distributed in basal ganglia/thalamus and infratentorial (62％) regions.The Age (70.8 ± 5.4 vs.67.3 ± 8.1; t =2.461,P =0.016),proportion of hypertension (80.0％ vs.52.7％ ;x2 =6.851,P =0.009),and 24 h mALB levels (16.257 ± 6.031 mg/24 h vs.11.910 ±5.458 mg/24 h; t =3.536,P =0.001) in the CBM group were significantly higher than those in the non-CMB group.Spearman rank correlation analysis showed that the 24 h mALB and the severity of CMB in patients with SAO showed a significant positive correlation (rs =0.795,P =0.000).The higher the 24 h mALB level was,the more severe the CMB degree would be.Multivariate logistic regression analysis showed that only 24 h mALB was the only independent risk factor for CMBs in patients with SAO (odds ratio,1.100,95％ confidence interval 1.031-1.176; P =0.002).Conclusions The 24 h mALB is an independent risk factor for CMB in patients with SAO.The 24 h mALB level is positively correlated with the severity of CMB,and it may be used as a marker for small vascular injury.
