Expression and significance of SIRT1 and p53 in endometrial carcinoma with diabetes mellitus

VernacularTitle:SIRT1和p53在合并糖尿病子宫内膜癌的表达及意义
Author: Hongying GUO ; Shuqin GUO ; Xiaodong CHENG ; Wenming ZHAO ; Zhihong LI ; Qian YANG
Publication Type:Journal Article
Keywords: Endometrial neoplasms; Diabetes mellitus,type 2; SIRT1; Genes,p53
From: Journal of International Oncology 2013;(3):236-239
CountryChina
Language:Chinese
Abstract: Objective To investigate the expressions and significances of SIRT1 and p53 in endometrial carcinoma with diabetes mellitus.Methods Immunohistochemistry was carried out to examine the expressions of SIRT1 and p53 in 39 cases of endometrial carcinoma with diabetes mellitus and 40 cases of endometrial carcinoma without diabetes mellitus and 25 cases of normal endometrium,and the correlations between these indexs were analysed.Results The positive rate of SIRT1 and p53 in experimental group was 64.1％,59.0％ respectively,and 85.0％,52.5％ in control group.The positive rate of SIRT1 in experimental group was lower than that of control group (x2 =4.561,P =0.033).The positive rates of SIRT1 and p53 in control group were higher than that of normal endometrium (x2 =21.462,P＜ 0.001; x2 =6.771,P =0.009).Expression of SIRT1 was positively correlated with p53 (r =0.360,P =0.024).Conclusions Hyperglycemia deregulates SIRT1 in endometrial carcinoma.SIRT1 may promote tumorigenesis by silence of p53.