Epithelial-mesenchymal transition and cancer stem cells
10.3760/cma.j.issn.1673-422X.2013.03.005
- VernacularTitle:上皮细胞间质转化与肿瘤干细胞
- Author:
Sufeng QIANG
;
Yong HUANG
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Neoplastic stem cells;
MicroRNAs;
Epithelial-mesenchymal transitions
- From:
Journal of International Oncology
2013;(3):177-180
- CountryChina
- Language:Chinese
-
Abstract:
Epithelial-mesenchymal transition (EMT) not only can endow cells migration and invasion characteristics,but also can make tumor cells obtain self-renewal ability and have the characteristics of stem cells,which might result in cancer stem cell (CSCs).There are the same molecular mechanism and microenvironment between EMT and CSCs,which have great clinic significances for the diagnosis and treatment of the aggressive cancers.Moreover,many studies show that miR-200 could regulate EMT and CSC,participate in the tumor invasion and metastasi,and promote the research of targeted cancer therapy.
