Oncogenic mechanism and biological effect of Evi-1 gene
10.3760/cma.j.issn.1673-422X.2013.03.003
- VernacularTitle:Evi-1基因的生物学作用及致肿瘤机制研究进展
- Author:
Xiangping DING
;
Jinhua ZHANG
- Publication Type:Journal Article
- Keywords:
Smad3 protein;
Leukemia;
Transforming growth factor beta;
Neoplasms;
Evi-1 gene
- From:
Journal of International Oncology
2013;(3):170-173
- CountryChina
- Language:Chinese
-
Abstract:
Ecotropic viral integration site-1 (Evi-1) gene is first identified as a binding site for retrovirus in murine myeloid leukemia.The human homologue with the murine in leukemia oncogene Evi-1 is about 91％ of nuclear sequence and 94％ of amino acid.Evi-1 gene is high expressed in myeloid malignancies and other tumors.The main tumorigenic mechanisms of Evi-1 gene include inhibiting TGF-β signal path by depressing Smad3,adjusting cell cycle,promoting angiogenesis,inhibiting JNK.activating AP-1,and so on.
