Mechanisms of STAT family mediated IDO regulation in dendritic cells
10.3760/cma.j.issn.1673-422X.2013.03.001
- VernacularTitle:STAT蛋白参与树突状细胞中IDO转录调控的研究进展
- Author:
Yue WANG
;
Jinpu YU
;
Xiubao REN
- Publication Type:Journal Article
- Keywords:
Trans-activation (genetics);
Suppressor of cytokine signaling proteins;
Dendritic cells
- From:
Journal of International Oncology
2013;(3):163-165
- CountryChina
- Language:Chinese
-
Abstract:
Indoleamine 2,3-dioxygenase (IDO) is known as an endogenous immunosuppressive enzyme which plays a significant role in the process of tumor.IDO is not only found in tumor cells but also detected in dendritic cell (DC) in tumor microenvironment,which participates in the formation of tumor immune tolerance through expressing IDO enzyme.Signal transducer and activator of transcription (STAT) is the main signal protein family which participates in the IDO transcriptional regulation of DC.It is necessary to detail the signaling pathway in regulating IDO expression,which will help us develop high specific and more active IDO inhibitors and provide new options for anti-cancer targeted therapy.
