Research progress of thioredoxin-related protein 14
10.3760/cma.j.issn.1673-422X.2013.02.002
- VernacularTitle:硫氧还蛋白相关蛋白14的研究
- Author:
Zhiqin FU
;
Xing XIE
;
Xiaodong CHENG
- Publication Type:Journal Article
- Keywords:
Thioredoxins;
Tumor necrosis facctor-alpha;
Thioredoxin-related protein 14
- From:
Journal of International Oncology
2013;(2):86-89
- CountryChina
- Language:Chinese
-
Abstract:
Thioredoxin-related protein 14 (TRP14),a new member of Trx family,is a novel disulfide reductase with conservative CPDC motif.Its structure and function are comparable to Trx,which is the representative member of Trx family.However,there are many differences.When tumor necrosis factor-α (TNF-α) induced cells to produce the active oxygen,TRP14 can change oxidatin state of dynein light chain(its substrate),act as a sensor of the intracellular redox state to regulate NF-κB signaling pathways induced by TNF-α,MAPK and apoptosis signaling pathways.
