Research progress of FLIP in cancer
10.3760/cma.j.issn.1673-422X.2013.02.001
- VernacularTitle:FLIP在肿瘤中的研究
- Author:
Jue SHEN
;
Yufeng LI
;
Zhenjuan HE
- Publication Type:Journal Article
- Keywords:
FLIP;
Apoptosis;
Signaling pathway;
Regulation
- From:
Journal of International Oncology
2013;(2):83-85
- CountryChina
- Language:Chinese
-
Abstract:
FLIP is a protein containing death domain.Human beings have three subtypes of c-FLIPL,c-FLIPs and c-FLIPR,which can inhibit the apoptosis of a variety of tumor cells.c-FLIPL plays a dual role in the apoptotic signal.The expression level of FLIP not only decides the opening and closing of the apoptosis pathway but also achieve the conversion of cells in the apeptotic signaling and proliferative signaling pathway.The regulation of FLIP's expression is a multi-layered,involving multiple signaling pathways.FLIP will probably become an attractive death receptor signaling target of therapy.
