Research progress on the regulatory mechanism of gastric cancer stem cell
10.3760/cma.j.issn.1673-422X.2013.01.017
- VernacularTitle:胃癌干细胞调控机制研究进展
- Author:
Chundong LIN
;
Jianchun CAI
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Neoplastic stem cells;
Epithelial-to-mesenchymal transition;
Signal transduction
- From:
Journal of International Oncology
2013;(1):57-61
- CountryChina
- Language:Chinese
-
Abstract:
Gastric cancer stem cells are defined as a subset of gastric cancer cells that possess stem cell properties,including self-renewal and multiplex differentiation potential,and have crucial roles in tumor initiation,progression,invasion,metastasis and recurrence.Epithelial-mesenchymal transition (EMT) can facilitate the invasion and metastasis of cancer cells to distant tissues,and confer the metastatic cancer cells some abilities of stem cells.Several transcription factors of EMT,signaling pathways and microRNAs (miRNAs) are involved in the process of regulating gastric cancer stem cells.
