Expression of leptin and leptin receptor in esophageal squamous cell carcinoma and its clinical significance
10.3760/cma.j.issn.1006-9801.2013.02.004
- VernacularTitle:瘦素及瘦素受体在食管鳞状细胞癌中的表达及其临床意义
- Author:
Shanbing WANG
;
Yumin JIA
;
Jiapei LIU
;
Kaijian LEI
;
Shuangping ZHANG
;
Mingzong HU
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms;
Neoplasms,squamous cell;
Lepptin;
Receptors
- From:
Cancer Research and Clinic
2013;(2):84-86
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship of leptin,leptin receptor and esophageal squamous cell carcinoma,and provide a scientific basis for prevention and treatment of esophageal cancer.Methods Samples were collected from 32 patients with esophageal squamous cell carcinoma,20 healthy control subjects in Shanxi Tumor Hospital.ELISA and immunohistochemistry were used to analyze leptin and leptin receptor,respectively.The correlation between their expression and clinicopathologieal parameters was also analysized.Results Patients with esophageal squamous cell carcinoma had significandy(t =4.64,P ＜ 0.001)higher leptin levels [(4.7 ±1.9)ng/ml] compared with normal [(2.54±1.01)ng/ml] oesophagus tissues.The expression rate of leptin receptor in esophageal carcinoma and normal esophagus was 81.25 ％ and 75.00 ％ respectively,not differ significantly.The expression levels of leptin was associated with position,(l)ymphatic metastasis.Conclusion Higher leptin levels seem to represent an additional,independent risk factor for esophageal squamous cell carcinoma,leptin receptor expression on oesophageal epithelial cells provides a pathway for leptin-mediated signal transduction.
