Application of serum surface-enhanced laser desorption/ionization proteomic patterns in esophageal carcinoma

VernacularTitle:血清蛋白指纹图谱在食管癌中的应用
Author: Jing WANG ; Wenjing DU ; Ruihong YANG ; Dan GUO ; Jingyi WANG ; Jie LI
Publication Type:Journal Article
Keywords: Esophageal neoplasms; Surface-enhanced laser desorption/ionization proteomic patterns
From: Cancer Research and Clinic 2013;(2):80-83
CountryChina
Language:Chinese
Abstract: Objective To analyse serum proteomic patterns'differences in esophageal carcinoma patients by proteinchip technology and study its clinical value.Methods Surface-enhanced laser desorption /ionization proteomic patterns and WCX-2 protein chip were respectively used to detect the serum proteomic patterns in esophageal carcinoma patients according to before and after radiation,IMRT or 2-dimensional radiotherapy and metastasis or not.The data were analyzed by using Biomarker Wizard software.Results 8 differential protein peaks whose M/Z were 2863,3884.213,1699.600,1371.126,8454.341,1141.881,1473.377,2086.908 and 2785.016 were significant before and after radiotherapy.8 protein peaks whose M/Z were 3470.098,2011.529,3395.789,2639.055,1511.632,11488.520,9546.555 and 4783.831 were significant between IMRT and 2-dimensional radiotherapy.2 protein peaks whose M/Z were 3470.098,3395.789 were significant between metastasis and not metastasis.Conclusion Serum surface-enhanced laser desorption / ionization proteomic patterns analysis has good prospects in evaluating therapeutic effect and prognosis of esophageal carcinoma patients.