Glutamate and early neurological deterioration in ischemic stroke
10.3760/cma.j.issn.1673-4165.2013.02.011
- VernacularTitle:谷氨酸与缺血性卒中早期神经功能恶化
- Author:
Yang WANG
;
Jiandong JIANG
- Publication Type:Journal Article
- Keywords:
Stroke;
Brain Ischemia;
Glutamic Acid;
Biological Markers;
Disease Progression
- From:
International Journal of Cerebrovascular Diseases
2013;(2):132-137
- CountryChina
- Language:Chinese
-
Abstract:
The mechanisms underlying early neurological deterioration (END) after ischemic stroke are not clear.There are no reliable predictive factors and effective preventive measures for END.The glutamatemediated excitotoxicity plays a very important role in the cascade reaction of ischemic events.High level of glutamate in plasma is one of the important predictors for END.Studies have shown that the polymorphism in the promoter of the excitatory amino acid transporter-2 gene is a potential cause for individual susceptibility to END.Some therapeutic strategies of interrupting the glutamatergic pathways may be as the strategies of intervention END.
