Application of combination detection of CA15-3, CEA, COX-2 on diagnosis of breast carcinoma

VernacularTitle:糖类抗原15-3、癌胚抗原、环氧合酶-2联合检测在乳腺癌诊断中的应用
Author: Benchuan LI ; Meihua GAO
Publication Type:Journal Article
Keywords: Breast neoplasms; Tumor maker; Combined detection
From: Cancer Research and Clinic 2013;(1):44-46
CountryChina
Language:Chinese
Abstract: Objective To investigate the value of combination detection of CA15-3,CEA,COX-2 on early diagnosis of breast carcinoma.Methods 68 breast cancer patients,61 benign breast disease patients and 68 healthies were selected.Serum levels of COX-2 were detected by ELISA technique,CA15-3 and CEA levels were detected by electroche-miluminescence technique.Results Serum levels of CA15-3,CEA,COX-2 in breast carcinoma group were (34.67±13.20) U/ml,(7.38±3.87) ng/ml,(43.25±10.87) ng/ml.Their levels were higher than those in benign breast disease group and healthy group,the differences were significant (P ＜ 0.01).In combination detection,the sensitivity was 84.9 ％,and accuracy was 91.2 ％,which were higher than single tumor marker used in breast cancer diagnosis.Conclusion The combined detection of CA15-3,CEA,COX-2 could increase the diagnosis rate of breast carcinoma.