Clinical observation on three-dimensional conformal radiotherapy combined with concurrent chemotherapy in the treatment of multiple primary carcinoma of esophagus
10.3760/cma.j.issn.1006-9801.2013.01.007
- VernacularTitle:三维适形放疗联合同期化疗治疗食管多发癌的临床观察
- Author:
Yibiao CHEN
;
Hanxiong ZHANG
;
Zhendong JIANG
;
Ting LIU
;
Wenbiao ZHU
;
Guoming DENG
- Publication Type:Journal Article
- Keywords:
Esophagus neoplasms;
Three-dimensional conformal radiotherapy;
Concurrent chemotherapy
- From:
Cancer Research and Clinic
2013;(1):22-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analysis of the efficacy and toxicity of multiple primary cancer of esophagus in three-dimensional conformal radiotherapy and concomitant chemotherapy.Methods Fifteen cases of multiple primary carcinoma of esophagus who refused the operation were collected.The Elekta linac 6 MV/10 MV X ray was used to conformal irradiation in three-four coplanar wild,2 Gy/time,1 time/day,5 times/week.The dose to the target area,CTV 40-50 Gy/4-5 weeks,GTV 60 Gy/6 weeks.TP scheme (paclitaxel+cisplatin) was used in the first day and 29th day,three-dimensional conformal radiation therapy initiated in the second day after chemotherapy.Results 1,3 year local control and overall survival were 86.7 ％ (13/15),33.4 ％ (5/15) and 73.3 ％ (11/15),26.6 ％ (4/15).Class 1-2 and class 3-4 acute radiation esophagitis and leukopenia occurred rates were 86.7 ％ (13/15),13.3 ％ (2/15) and 80 ％ (12/15),20 ％ (3/15).Conclusion Radiation therapy is the better treatment method for multiple primary carcinoma of esophagus when proximal lesions located in upper thoracic and cervical high.Toxic and side-effects can be tolerated of three dimensional conformal radiation therapy combined with chemotherapy in the treatment of multiple esophageal cancer.
