Relation between breast cancer susceptibility gene 1 expression and the efficacy of platinum-based chemotherapy in colorectal cancer
10.3760/cma.j.issn.0254-1432.2013.03.010
- VernacularTitle:结直肠癌组织乳腺癌易感基因1的表达及与铂类化学治疗疗效的关系
- Author:
Guanghui XU
;
Yu LI
;
Yi LIU
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Genes;
BRCA1;
Organoplatinum compounds;
Drug resistance;
neoplasm;
Prognosis
- From:
Chinese Journal of Digestion
2013;(3):184-186
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of breast cancer susceptibility gene 1 (BRCA1) in human colorectal cancer and its correlation with the efficacy of platinum-based chemotherapy.Methods Seventy-eight cases of colorectal cancer patients treated with platinum-based chemotherapy after surgery were collected.The surgical specimens of them were taken.Fourteen normal colonic mucosa specimens and 12 non-cancerous tissues of colorectal cancer specimens were obtained.The expression of BRCA1 in tissues was detected by immunohistochemistry and analyzed by x2 test.The colorectal cancer patients were followed up for survival time.Comparison of survival analysis was performed by Kaplan-Meier survival curves and Log-rank test.Results The positive rate of the BRCA1 expression in colorectal cancer tissue (52.6 ％,41/78) was lower than that of para-cancer tissue (11/12,x2 =6.518,P=0.011) and normal colonic mucosa tissue (13/14,x2 =7.949,P=0.005).The poorer the differentiation of colorectal cancer,the lower the positive rate of BRCA1 (x2=14.160,P=0.001).The median disease-free survival time of BRCA1 negative colorectal cancer patients was 51.0 months (95 ％ CI:47.7 to 54.4 months),which was longer than that of BRCA1 positive patients (45.0 months,95 ％CI:36.6 to 53.4 months,x2 =4.367,P=0.032).Conclusions Receiving oxaliplatin based chemotherapy may be a survival benefit for BRCA1 negative colorectal cancer patients.The expression of BRCA1 may be an index for chemotherapy options and prognosis evaluation for colorectal cancer patients after surgery.
