Impact of visit-to-visit variability in blood pressure on renal function of stage 3-4 chronic kidney diseases patients with hypertension
10.3760/cma.j.issn.1001-7097.2013.02.004
- VernacularTitle:诊间血压变异性对肾功能中度受损高血压患者肾功能的影响
- Author:
Daoxin YIN
;
Dongliang ZHANG
;
Rui XU
;
Xuefei LENG
;
Wenying CUI
;
Wenhu LIU
- Publication Type:Journal Article
- Keywords:
Kidney diseases;
Hypertension;
Variability,blood pressure
- From:
Chinese Journal of Nephrology
2013;(2):98-102
- CountryChina
- Language:Chinese
-
Abstract:
Objective To clarify the clinical significance of visit-to-visit variability in blood pressure (BP) of stage 3-4 chronic kidney disease (CKD) patients with hypertension.Methods One hundred and fifty-two cases of stage 3-4 CKD patients with hypertension were enrolled in the study.Variability in BP was defined as the standard deviation (SD) in BP.For each patient,SD and mean BP from BP measurements were calculated at all the visits.Correlations between the decline in estimated glomerular filtration rate (eGFR) and SD in BP were analyzed by multivariable regression.Results Visit-to-visit variability in BP was significantly associated with renal function decline (P ＜ 0.05),in addition,baseline eGFR,baseline albuminuria and mean SBP during follow-up were significantly associated with renal function decline as well (all P ＜ 0.05).The percentage of CCBs used in low SD of the SBP group was higher than that in high SD of the SBP (76.1％ vs 58.2％,P ＜ 0.05).Conclusion Visit-to-visit variability in BP is significantly associated with renal function decline.Drugs which can decrease the variability of blood pressure should be the first choice in the treatment of hypertension.
